Job opening
Senior Scientist
Filed under Pharmaceutical Manufacturing
Full job description
Job Details:
Position: Senior Scientist
Location: Emeryville, CA
Duration: 18 Months (High Possibility of Extension)
Responsibilities:
- Design, develop, and execute in vitro ADME assays to support drug discovery and candidate optimization.
- Conduct ADME screening studies, including but not limited to microsomal stability, hepatocyte stability, permeability, plasma protein binding, and related metabolism assays.
- Generate, analyze, interpret, and report high-quality data to support project decisions and compound progression.
- Design and troubleshoot in vitro experiments to address project-specific questions related to compound metabolism, stability, permeability, and protein binding.
- Contribute to LC-MS/MS bioanalytical method development, sample analysis, assay optimization, and troubleshooting.
- Apply enzyme kinetic and quantitative bioanalytical principles to support assay design and data interpretation.
- Maintain accurate documentation in electronic laboratory notebooks and ensure adherence to internal quality and safety standards.
- Support implementation and use of laboratory automation platforms, as applicable.
Qualifications:
- BS or MS in chemistry, biochemistry, pharmacology, pharmaceutical sciences, biology, or a related scientific discipline.
- Minimum of 2 years of relevant hands-on in vitro ADME experience in a biopharmaceutical, pharmaceutical, or contract research organization environment.
- Strong understanding of DMPK and ADME principles, including assay design, data analysis, and interpretation.
- Demonstrated experience designing and executing automated in vitro assays to evaluate and optimize ADME properties of drug candidates.
- Hands-on experience with LC-MS/MS-based sample analysis; experience with Sciex instruments is preferred.
- Proficiency with data analysis and visualization tools such as Microsoft Excel, GraphPad Prism, Analyst, or similar software.
- Experience using electronic laboratory notebooks.
- Experience with laboratory automation platforms such as Hamilton, Tecan, or similar systems is preferred.